A simulated process for microcrystalline cellulose granulation via roller compaction is considered. The historical dataset was created via gSOLIDS, and 40 distinct samples were considered. The following eight inputs were supposed to be known: granulate compressibility factor, friction angle between solid granulate and roller compactor, effective angle of friction, springback factor, roller diameter, roller width, roller speed, and roller pressure. The quality of interest is the intravoid fraction of Microcrystalline Cellulose particles exiting the roller compactor (y).
The data was generated using five different kinds of microcrystalline cellulose and two different roller compactors. A particulate coprocessed synthesis with MCC and at least one sugar alcohol was developed. Mannitol was the flavoured sugar alcohol. In the development of solid dose formulations, such as tablets, the structure had a better compressibility profile, lubricant affectability, and ejection profile than Microcrystalline Cellulose plus at least one sugar alcohol, either alone or in a blend as a simple dry mix. The additive was made up of MCC and at least one sugar alcohol in a 70:30 to 95:5 ratio.
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